Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells
5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the ...
29 Nov 2011 ... We found that 5-OH-HxMF can effectively induce PC12 neurite outgrowth ... Consistently, 5-OH-HxMF treatment increased the intracellular cAMP level and downstream component, PKA activity. ... Facebook · Share on Twitter ...